Osman, O., Kamel, I., Elshereif, A., Mohamed, A., Magdy, A. (2020). Effect of Platelet Rich Plasma (PRP) on Bone Graft in Alveolar Cleft Repair. The Egyptian Journal of Plastic and Reconstructive Surgery, 43(3), 417-424. doi: 10.21608/ejprs.2020.68177
Omar Osman; Ibrahim H Kamel; Ahmed Elshereif; Ahmed M Mohamed; Amr Magdy. "Effect of Platelet Rich Plasma (PRP) on Bone Graft in Alveolar Cleft Repair". The Egyptian Journal of Plastic and Reconstructive Surgery, 43, 3, 2020, 417-424. doi: 10.21608/ejprs.2020.68177
Osman, O., Kamel, I., Elshereif, A., Mohamed, A., Magdy, A. (2020). 'Effect of Platelet Rich Plasma (PRP) on Bone Graft in Alveolar Cleft Repair', The Egyptian Journal of Plastic and Reconstructive Surgery, 43(3), pp. 417-424. doi: 10.21608/ejprs.2020.68177
Osman, O., Kamel, I., Elshereif, A., Mohamed, A., Magdy, A. Effect of Platelet Rich Plasma (PRP) on Bone Graft in Alveolar Cleft Repair. The Egyptian Journal of Plastic and Reconstructive Surgery, 2020; 43(3): 417-424. doi: 10.21608/ejprs.2020.68177
Effect of Platelet Rich Plasma (PRP) on Bone Graft in Alveolar Cleft Repair
1The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Minia* University
2The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Ain Shams University
3The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Minia University
Abstract
Background: Ultimate repair of alveolar defects is a great challenge in practical field, many bone graft materials have been evolved in the literatures for alveolar defect reconstruction as autogenous, allogenic, xenogenic, and alloplastic grafts [1], autogenous iliac crest bone graft is the gold standard among other graft materials evaluated. However, the procedure associated with a potential risk of early complications such as graft resorption, graft leakage, infection, or graft failure, failure rate is about 30% [2]. Objectives: To assess the efficacy of using Platelet Rich Plasma (PRP) in alveolar cleft reconstruction; in combination with Iliac Crest Bone Graft (ICBG) in comparison to the conventional Iliac Crest Bone Grafting (ICBG). Patients and Methods: 20 patients underwent alveolar cleft reconstruction at the age of mixed dentition over a 3- year's period; their mean age was 8.8±2.3 years years and their mean post-operative follow-up was 13.4 months. Of these, 10 patients treated with ICBG combined with PRP (Group I), and 10 patients repaired by ICBG alone Group II (control group) results were assessed by rating the radiographs obtained 3, 6, and 12 months post-operatively according to cone beam CT (CBCT) volume and density assessment. Results: Alveolar cleft repairs using PRP combined cancellous bone (Group I) were 90 percent successful, alveolar cleft repairs using cancellous bone (Group I) were 70 percent successful as regard; bone resorption reduction, bone volume gaining and improved bone density in CBCT at 3, 6, and 12 months post-operative with decreased post-operative complication rates. Conclusion: Application of PRP enhances bone formation in alveolar clefts when admixed with autologous bone graft harvested from the iliac crest as it leads to early bone formation, increased bone density, decreases bone resorption, low infection rate and least post-operative complications.
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