Serum Albumin and Interleukin 6 Levels as Risk Factors of Morbidity and Mortality in Burn Patients

SHORBA, MOHAMED AHMED SAAD; Shalaby, Helmy Ahmed; Almetaher, Hisham Almohamady; Ghoraba, Samir Mohamed

doi:10.21608/ejprs.2025.425155

Serum Albumin and Interleukin 6 Levels as Risk Factors of Morbidity and Mortality in Burn Patients

Document Type : Research article

Authors

¹ The Department of General Surgery, Faculty of Medicine, Tanta University

² The Department of Plastic & Reconstruction Surgery, Faculty of Medicine, Tanta University

³ The Department of Paediatric Surgery, Faculty of Medicine, Tanta University

10.21608/ejprs.2025.425155

Abstract

Background: Interleukin-6 (IL-6) is a major player in setting
off this cascade of inflammatory responses. The loss of
plasma proteins like albumin and a decrease in plasma colloid
Osmotic pressure led to increased fluid leakage from blood capillaries
into normal tissue and the lungs.
Objective: The objective of this investigation was to evaluate
serum albumin and IL-6 levels as risk factors of morbidity
and mortality in burn patients.
Patients and Methods: The prospective cohort investigation
was conducted on 25 burn patients aged from 8 to 70 years,
both sexes, with second- or third-degree burns, scald, or flame
Burn if the surface area is >15%. IL-6 and serum albumin were
measured at first, third, and seventh days in all patients.
Results: The body surface burned and abbreviated burn
severity index (ABSI) were significantly increased in non-survivors
than survivors (p < 0.001). Sodium and albumin were significantly
decreased in non-survivors than survivors (p < 0.05).
Potassium and IL-6 were significantly increased in non-survivors
than survivors (p < 0.05). Albumin was significantly decreased
after 3 days than on admission (p < 0.001) and it was
significantly decreased after 1 week than on admission and after
3 days (p < 0.05). IL-6 was significantly increased after 3 days
and 1 week than on admission (p < 0.001). The length of hospital
stay was significantly higher in survivors than in non-survivors
(p=0.048) and it increased with an increase in total body surface area.
Conclusions: Serum albumin and IL-6 levels were strongly
correlated with injury severity and progression.

Keywords

Main Subjects

Burns

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