SHORBA, M., Shalaby, H., Almetaher, H., Ghoraba, S. (2025). Serum Albumin and Interleukin 6 Levels as Risk Factors of Morbidity and Mortality in Burn Patients. The Egyptian Journal of Plastic and Reconstructive Surgery, 49(2), 169-175. doi: 10.21608/ejprs.2025.425155
MOHAMED AHMED SAAD SHORBA; Helmy Ahmed Shalaby; Hisham Almohamady Almetaher; Samir Mohamed Ghoraba. "Serum Albumin and Interleukin 6 Levels as Risk Factors of Morbidity and Mortality in Burn Patients". The Egyptian Journal of Plastic and Reconstructive Surgery, 49, 2, 2025, 169-175. doi: 10.21608/ejprs.2025.425155
SHORBA, M., Shalaby, H., Almetaher, H., Ghoraba, S. (2025). 'Serum Albumin and Interleukin 6 Levels as Risk Factors of Morbidity and Mortality in Burn Patients', The Egyptian Journal of Plastic and Reconstructive Surgery, 49(2), pp. 169-175. doi: 10.21608/ejprs.2025.425155
SHORBA, M., Shalaby, H., Almetaher, H., Ghoraba, S. Serum Albumin and Interleukin 6 Levels as Risk Factors of Morbidity and Mortality in Burn Patients. The Egyptian Journal of Plastic and Reconstructive Surgery, 2025; 49(2): 169-175. doi: 10.21608/ejprs.2025.425155
Serum Albumin and Interleukin 6 Levels as Risk Factors of Morbidity and Mortality in Burn Patients
1The Department of General Surgery, Faculty of Medicine, Tanta University
2The Department of Plastic & Reconstruction Surgery, Faculty of Medicine, Tanta University
3The Department of Paediatric Surgery, Faculty of Medicine, Tanta University
4The Department of Plastic & Reconstruction Surgery, Faculty of Medicine, Tanta University
Abstract
Background: Interleukin-6 (IL-6) is a major player in setting off this cascade of inflammatory responses. The loss of plasma proteins like albumin and a decrease in plasma colloid Osmotic pressure led to increased fluid leakage from blood capillaries into normal tissue and the lungs. Objective: The objective of this investigation was to evaluate serum albumin and IL-6 levels as risk factors of morbidity and mortality in burn patients. Patients and Methods: The prospective cohort investigation was conducted on 25 burn patients aged from 8 to 70 years, both sexes, with second- or third-degree burns, scald, or flame Burn if the surface area is >15%. IL-6 and serum albumin were measured at first, third, and seventh days in all patients. Results: The body surface burned and abbreviated burn severity index (ABSI) were significantly increased in non-survivors than survivors (p < 0.001). Sodium and albumin were significantly decreased in non-survivors than survivors (p < 0.05). Potassium and IL-6 were significantly increased in non-survivors than survivors (p < 0.05). Albumin was significantly decreased after 3 days than on admission (p < 0.001) and it was significantly decreased after 1 week than on admission and after 3 days (p < 0.05). IL-6 was significantly increased after 3 days and 1 week than on admission (p < 0.001). The length of hospital stay was significantly higher in survivors than in non-survivors (p=0.048) and it increased with an increase in total body surface area. Conclusions: Serum albumin and IL-6 levels were strongly correlated with injury severity and progression.
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