Saad Eldin, M., Mahmoud, A., El Meghawry, K., Mohamed, R., Tallal, R. (2024). Guideline of Management of Acute Smoke Inhalation Injury: Systematic Review and Meta-Analysis of Last 10 Years. The Egyptian Journal of Plastic and Reconstructive Surgery, 48(4), 245-254. doi: 10.21608/ejprs.2024.385090
Mohamed Osama Saad Eldin; Ahmed Ali Mahmoud; Khaled Mohamed El Meghawry; Reffaat Abd Elsabour Mohamed; Raghda Elsayed Tallal. "Guideline of Management of Acute Smoke Inhalation Injury: Systematic Review and Meta-Analysis of Last 10 Years". The Egyptian Journal of Plastic and Reconstructive Surgery, 48, 4, 2024, 245-254. doi: 10.21608/ejprs.2024.385090
Saad Eldin, M., Mahmoud, A., El Meghawry, K., Mohamed, R., Tallal, R. (2024). 'Guideline of Management of Acute Smoke Inhalation Injury: Systematic Review and Meta-Analysis of Last 10 Years', The Egyptian Journal of Plastic and Reconstructive Surgery, 48(4), pp. 245-254. doi: 10.21608/ejprs.2024.385090
Saad Eldin, M., Mahmoud, A., El Meghawry, K., Mohamed, R., Tallal, R. Guideline of Management of Acute Smoke Inhalation Injury: Systematic Review and Meta-Analysis of Last 10 Years. The Egyptian Journal of Plastic and Reconstructive Surgery, 2024; 48(4): 245-254. doi: 10.21608/ejprs.2024.385090
Guideline of Management of Acute Smoke Inhalation Injury: Systematic Review and Meta-Analysis of Last 10 Years
1The Departments of Plastic, Burn, Reconstructive & Maxillofacial Surgery, Faculty of Medicine, Ain Shams University
2The Departments Anaesthesia, Intensive Care & Pain Management, Faculty of Medicine, Ain Shams University
Abstract
Abstract Background: Inhalation injury-based respiratory failure is the main cause of death in patients with severe burns. In general, damage from smoke inhalation results in airway edema, inflammation and, subsequently, cellular debris, mucus, fibrin clots and polymorphonuclear leukocytes PNL combine to form casts that lead to ventilation/perfusion mismatch and poor oxygenation. Objective: This meta-analysis aims to review the Guideline of Management of Acute Smoke Inhalation Injury and discuss the different modalities and treatment. Material and Methods: A comprehensive search of the literature to identify the Guideline of Management of Acute Smoke Inhalation Injury and discuss the different modalities and treatment. via electronic databases including OVID, Science Direct, Springer, Web of Science and Google Scholar. Initial search will carried out using keywords: “burns, “ARDS,” “adult respiratory distress syndrome”, “extracorporeal membrane oxygenation”, “ECMO,” “inhalation injury”, ”smoke inhalation injury”, and “heparinized oxygen mask”, ”ECMO”. Results: All published articles were from 2013 to 2022 limited to human studies of different modalities will be analyzed and compared regarding the criteria of management. Conclusion: The care of patients with burn related inhalation injury remains highly challenging. Key topics include airway management, nebulized heparin, NAC, chest physiotherapy and ECMO effect. Early ambulation, nebulized Heparin in combination with NAC and albuterol was associated with a reduction in the duration of mechanical and decrease mortality rate. Key Words: Acute Smoke Inhalation Injury – Burn Injuries – Nebulized Heparin – Chest Physiotherapy – ECMO Effect.
Guo G., Zhu F., Huang Y., et al.: National Expert Consensus on clinical diagnosis and treatment of inhalation injury (2018). Chin J Burns, 34 (11): 770–5, 2018. 2- Ma H., Tung K.Y., Tsai S.L., et al.: Assessment and determinants of global outcomes among 445 mass-casualty burn survivors: A 2-year retrospective cohort study in Taiwan. Burns, 46: 1444–1457, 2020. 3- Palmieri T.L.: Inhalation injury: Research progress and needs. J. Burn Care Res., 28: 549–554, 2017. 4- Gupta K., Mehrotra M., Kumar P., et al.: Smoke inhalation injury: Etiopathogenesis, diagnosis, and management. Indian J Crit Care Med., 22: 180–8, 2018. 5- Hampson N.B.: Noninvasive pulse CO-oximetry expedites evaluation and management of patients with carbon monoxide poisoning. Am J Emerg Med., 30: 2021–4, 2012. 6- Nosanov L.B., McLawhorn M.M., Vigiola Cruz M., et al.: A national perspective on ECMO utilization use in patients with burn injury. Journal of Burn Care & Research, 39 (1): 10-4, 2017. 7- Foncerrada G., Lima F, Clayton R.P., et al.: Safety of nebulized epinephrine in smoke inhalation injury. Journal of Burn Care & Research, 38 (6): 396-402, 2017. 8- Ainsworth C.R., Dellavolpe J., Chung K.K., et al.: Revisiting extracorporeal membrane oxygenation for ARDS in Vol. 48, No. 4 / Guideline of Management of Acute S 254 moke Inhalation Injury burns: A case series and review of the literature. Burns, 44 (6): 1433-8, 2018. 9- Marcus J.E., Piper L.C., Ainsworth C.R., et al.: Infections in patients with burn injuries receiving extracorporeal membrane oxygenation. Burns, 45 (8): 1880-7, 2019. 10- Eldredge R.S., Zhai Y. and Cochran A.: Effectiveness of ECMO for burn-related acute respiratory distress syndrome. Burns, 45 (2): 317-21, 2019. 11- Kashefi N.S., Nathan J.I. and Dissanaike S.: Does a nebulized heparin/N-acetylcysteine protocol improve outcomes in adult smoke inhalation?. Plastic and Reconstructive Surgery Global Open., 2 (6), 2014. 12- Burke C.R., Chan T. and McMullan D.M.: Extracorporeal life support use in adult burn patients. Journal of Burn Care & Research, 38 (3): 174-8, 2017. 13- Li H.S., Yuan Z.Q., Song H.P., et al.: Clinical application of extracorporeal membrane oxygenation in the treatment of burn patients with acute respiratory distress syndrome: a retrospective analysis and systematic review. Zhonghua Shao Shang za zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns, 37 (10): 911-20, 2021. 14- Ding H., Lv Q., Wu S., et al.: Intratracheal instillation of perfluorohexane modulates the pulmonary immune microenvironment by attenuating early inflammatory factors in patients with smoke inhalation injury: A randomized controlled clinical trial. Journal of Burn Care & Research, 38 (4): 251-9, 2017. 15- McGinn K.A., Weigartz K., Lintner A., et al.: Nebulized heparin with N-acetylcysteine and albuterol reduces duration of mechanical ventilation in patients with inhalation injury. Journal of pharmacy practice, 32 (2): 163-6, 2019. 16- Elsharnouby N.M., Eid HE, Abou Elezz N.F., et al.: Heparin/ N-acetylcysteine: An adjuvant in the management of burn inhalation injury: A study of different doses. Journal of critical care, 29 (1): 182-e1, 2014. 17- Allam N.M. and Badawy M.M.: Does high-frequency chest wall oscillation have an impact on improving pulmonary function in patients with smoke inhalation injury?. Journal of Burn Care & Research, 42 (2): 300-4, 2021. 18- Szentgyorgyi L., Shepherd C., Dunn K.W., et al.: Extracorporeal membrane oxygenation in severe respiratory failure resulting from burns and smoke inhalation injury. Burns, 44 (5): 1091-9, 2018. 19- McIntire A.M., Harris S.A., Whitten J.A., et al.: Outcomes following the use of nebulized heparin for inhalation injury (HIHI Study). Journal of burn care & research, 38 (1): 45-52, 2017. 20- Behr C.A., Strotmeyer S.J., Swol J., et al.: Characteristics and outcomes of extracorporeal life support in pediatric trauma patients. Journal of Trauma and Acute Care Surgery, 89 (4): 631-5, 2020. 21- Dadras M., Wagner J.M., Wallner C., et al.: Extracorporeal membrane oxygenation for acute respiratory distress syndrome in burn patients: A case series and literature update. Burns & Trauma, 7, 2019. 22- Kubo T., Osuka A., Kabata D., et al.: Chest physical therapy reduces pneumonia following inhalation injury. Burns, 47 (1): 198-205, 2021. 23- Soussi S., Gallais P., Kachatryan L., et al.: Extracorporeal membrane oxygenation in burn patients with refractory acute respiratory distress syndrome leads to 28% 90-day survival. Intensive Care Medicine, 42: 1826-7, 2016. 24- Hsu P.S., Tsai Y.T., Lin C.Y., et al.: Benefit of extracorporeal membrane oxygenation in major burns after stun grenade explosion: Experience from a single military medical center. Burns, 43 (3): 674-80, 2017. 25- Sharma A. and Lunawat A.: Role of heparin and N-acetylcystein in prevention of acute respiratory distress syndrome in suspected inhalation injury in burn. Indian Journal of Basic and Applied Medical Research, 337-43, 2005. 26- Foncerrada G., Culnan D.M., Capek K.D., et al.: Inhalation injury in the burned patient. Ann. Plast. Surg., 80 (3): S98–S105, 2018. 27- Bai C., Huang H., Yao X., et al.: Application of flexible bronchoscopy in inhalation lung injury. Diagnostic pathology, 8: 1-5, 2013. 28- Jones S.W., Williams F.N., Cairns B.A., et al.: Inhalation injury: Pathophysiology, diagnosis, and treatment. Clin. Plast. Surg., 44: 505–11, 2017. 29- Niederman M.S., Ohtani M., et al.: Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with gram-negative pneumonia. Dis., 20 (3): 330–340, 2020. 30- Tredget E.E., et al.: “The role of inhalation injury in burn trauma. A Canadian experience.” Annals of Surgery, Vol. 212 (6): 720-7, 1990.