Gadallah, A., Elbarbary, A., Abdelsalam, A., Gamal El Deen, N., Abdel Gawad, E. (2022). The Effect of Heparin Injection Into Cut Ends of Flexor Tendon Zone II Injuries. The Egyptian Journal of Plastic and Reconstructive Surgery, 46(3), 239-246. doi: 10.21608/ejprs.2022.254713
Ahmed Gadallah; Amir Elbarbary; Ahmed Abdelsalam; Noha M. Gamal El Deen; Ebrahim M. A. Abdel Gawad. "The Effect of Heparin Injection Into Cut Ends of Flexor Tendon Zone II Injuries". The Egyptian Journal of Plastic and Reconstructive Surgery, 46, 3, 2022, 239-246. doi: 10.21608/ejprs.2022.254713
Gadallah, A., Elbarbary, A., Abdelsalam, A., Gamal El Deen, N., Abdel Gawad, E. (2022). 'The Effect of Heparin Injection Into Cut Ends of Flexor Tendon Zone II Injuries', The Egyptian Journal of Plastic and Reconstructive Surgery, 46(3), pp. 239-246. doi: 10.21608/ejprs.2022.254713
Gadallah, A., Elbarbary, A., Abdelsalam, A., Gamal El Deen, N., Abdel Gawad, E. The Effect of Heparin Injection Into Cut Ends of Flexor Tendon Zone II Injuries. The Egyptian Journal of Plastic and Reconstructive Surgery, 2022; 46(3): 239-246. doi: 10.21608/ejprs.2022.254713
The Effect of Heparin Injection Into Cut Ends of Flexor Tendon Zone II Injuries
1The Departments of Plastic, Burn & Maxillofacial Surgery, Faculty of Medicine, Ain Shams University
2The Departments of Diagnostic & Interventional Radiology, Faculty of Medicine, Ain Shams University
Abstract
Background: Because the FDP (flexor digitorum profundus) and the two slips of the FDS (flexor digitorum superficialis) are crowded within a tight fibro-osseous tunnel, it has never been easy to have good functional results after flexor tendon restoration in zone II, elevating the possibility of postoperative adhesions and a decrease in post-operative range of motion and power. Main aims of tendon repair are improved tendon healing and adhesion reduction. Primary flexor tendon healing methods are still being refined to this day. Aim of the Work: The goal is to assess the outcomes of heparin injection into cut ends of flexor tendon zone II injuries both clinically and radiologically using musculoskeletal ultrasound. Patients and Methods: This is an interventional clinical trial including forty individuals with flexor tendon injuries zone II. The Patients were sampled randomly into two groups, group I twenty patients (study group) with heparin injection and group II twenty patients (control group) without heparin injection. Results: Forty cases were included in our study which had zone II flexor tendon injury repaired using four strand techniques. Both groups had the same protocol of physiotherapy and follow-up. Results were measured as regards the total range of motion according to Strickland criteria showing no significant change between the two groups. Heparin injection shows a higher rupture rate of flexor tendons which were injected also showing gap formation in MSK US. Also, heparin injection increases the formation of granulation tissue which negatively affects the gliding of tendon. So, heparin injection is not recommended in flexor tendon repair zone II. Conclusion: Heparin injection shows a higher rupture rate of flexor tendons which were injected also which reflect gap formation in MSK US. Also, heparin injection increases the formation of adhesive granulation tissue which negatively affects the gliding of tendon. So, heparin injection is not recommended in flexor tendon repair zone II. However, there were a few limitations to our 239 study such as poor compliance of some patients which is considered one of the major problems that affect the postoperative outcomes.
1- Griffin M., Hindocha S., Jordan D., Saleh M. and Khan W.: An Overview of the Management of Flexor Tendon Injuries. The Open Orthopaedics Journal, Suppl (1): 6; 28, 2012. 2- Sadek A.F., Hweidi A.S. and Ahmed M.A.: Outcomes of staged reconstruction of Zone 2 flexor tendon injuries in recent wide-awake surgical settings and an earlier case series. Journal of Hand Surgery (European Volume), 17531934211053267, 2021. 3- Giesen T. and Elliot D.: Avoidance of unfavourable results following primary flexor tendon surgery. Indian Journal of Plastic Surgery, 46 (02): 312-324, 2013. 4- UslU M., Isik C., Ozsahin M., Ozkan A.R.I . . F., Yasar M., Orhan Z. and Sarman H.: Flexor tendons repair: Effect of core sutures caliber with increased number of suture strands and peripheral sutures. A sheep model. Orthopaedics & Traumatology: Surgery & Research, 100 (6): 611- 616, 2014. 5- Frueh F.S., Kunz V.S., Gravestock I.J., Held L., Haefeli M., Giovanoli P. and Calcagni M.: Primary flexor tendon repair in zones 1 and 2: Early passive mobilization versus controlled active motion. The Journal of Hand Surgery, 39 (7): 1344-1350, 2014. 6- Thomopoulos S., Kim H.M., Das R., Silva M.J., Sakiyamaelbert S., Amiel D. and Gelberman R.H.: The effects of exogenous basic fibroblast growth factor on intrasynovial flexor tendon healing in a canine model. The Journal of Bone and Joint Surgery. American Volume, 92 (13): 2285, 2010. 7- McDonald E., Gordon J.A., Buckley J.M. and Gordon L.: Comparison of a new multifilament stainless steel suture with frequently used sutures for flexor tendon repair. The Journal of Hand Surgery, 36 (6): 1028-1034, 2011. 8- Tang J.B., Zhang Y., Cao Y. and Xie R.G.: Core suture purchase affects strength of tendon repairs. The Journal of Hand Surgery, 30 (6): 1262-1266, 2005. 9- Wada A., Kubota H., Miyanishi K., Hatanaka H., Miura H. and Iwamoto Y.: Comparison of postoperative early active mobilization and immobilization in vivo utilising a four-strand flexor tendon repair. Journal of Hand Surgery, 26 (4): 301-306. 2001. 10- Peck F.H.: Customizing flexor rehabilitation based on zone or type of injury. Tendon Surgery of the Hand. Philadelphia, Elsevier Saunders, 415-26, 2012. 11- Akbari H., Rahimi A.A.K., Ghavami Y., Mousavi S.J. and Fatemi M.J.: Effect of heparin on post-operative adhesion in flexor tendon surgery of the hand. Journal of Hand and Microsurgery, 7 (02): 244-249, 2015. 12- Page C.: Heparin and related drugs: Beyond anticoagulant activity. International Scholarly Research Notices, pp. 2013, 2013. 13- Gupta A., Verghese T.J., Gupta P. and Gupta A.K.: Role of topical heparin in the management of burns: Experience in a district government hospital of Karnataka in South India. Plastic and Aesthetic Research, 2: 111-114, 2015. 14- Manzoor S., Khan F.A., Muhammad S., Qayyum R., Muhammad I., Nazir U. and Bashir M.M.: Comparative study of conventional and topical heparin treatment in second degree burn patients for burn analgesia and wound healing. Burns, 45 (2): 379-386, 2019. 15- Oremus M., Hanson M.D., Whitlock R., Young E., Archer C., Dal Cin A. and Raina P.: A systematic review of heparin to treat burn injury. Journal of Burn Care & Research, 28 (6): 794-804, 2007. 16- Mousavi S., Moradi M., Khorshid Ahmad T. and Motamedi M.: Anti-inflammatory effects of heparin and its derivatives: A systematic review. Advances in Pharmacological Sciences, pp. 2015, 2015. 17- Georgiou A., Singh P. and Mosahebi A.: Significance of Ultrasound-Guided Approach to the Operative Repair of Zone 2 Flexor Tendon Injuries. Plastic and Reconstructive Surgery, 147 (4): 719e-721e, 2021. 18- Goggins T., Syme D. and Murali S.R. (iv): Acute flexor tendon injury and rehabilitation of hand injuries. Orthopaedics and Trauma, 28 (4): 219-224, 2014. 19- Strickland J.W. and Glogovac S.V.: Digital function following flexor tendon repair in zone II: A comparison of immobilization and controlled passive motion techniques. The Journal of Hand Surgery, 5 (6): 537-543, 1980. 20- El-Deek A.M.F. and Hassan Dawood E.M.A.EH.: Role of ultrasonography in evaluation of tendons abnormalities in hand and fingers. Egypt J. Radiol. Nucl. Med., 50 (1): 108-119, 2019. 21- Hodgson R.J., O'connor P.J. and Grainger A.J.: Tendon and ligament imaging. The British Journal of Radiology, 85 (1016): 1157-1172, 2012. 22- Unsal S.S., Yildirim T. and Armangil M.: Comparison of surgical trends in zone 2 flexor tendon repair between Turkish and international surgeons. Acta Orthopaedica et Traumatologica Turcica, 53 (6): 474-477, 2019. 23- Strickland J.W.: Development of flexor tendon surgery: Twenty-five years of progress. Journal of Hand Surgery, 25 (2): 214-235, 2000. 24- Starnes T., Saunders R.J. and Means Jr., K.R.: Clinical outcomes of zone II flexor tendon repair depending on mechanism of injury. The Journal of Hand Surgery, 37 (12): 2532-2540, 2012. 25- Sandow M.J. and Mcmahon M.: Active mobilisation following single cross grasp four-strand flexor tenorrhaphy (Adelaide repair). Journal of Hand Surgery (European Volume), 36 (6): 467-475, 2011. 26- Higgins A., Lalonde D.H., Bell M., Mckee D. and Lalonde J.F.: Avoiding flexor tendon repair rupture with intraoperative total active movement examination. Plastic and Reconstructive Surgery, 126 (3): 941-945, 2010. 27- Al-Qattan M.M.: Zone 2 lacerations of both flexor tendons of all fingers in the same patient. Journal of Hand Surgery (European Volume), 36 (3): 205-209, 2011. 28- Tang J.B.: Flexor tendon repair in zone 2C. The Journal of Hand Surgery: British & European Volume, 19 (1): 72-75, 1994. 29- Elliot D., Moiemen N.S., Flemming A.F.S., Harris S.B. and Foster A.J.: The rupture rate of acute flexor tendon repairs mobilized by the controlled active motion regimen. Journal of Hand Surgery, 19 (5): 607-612, 1994. 246 Vol. 46, No. 3 / Heparin Injection Into Cut Ends of Flexor Tendon Zone II Injuries 30- Chesney A., Chauhan A., Kattan A., Farrokhyar F. and Thoma A.: Systematic review of flexor tendon rehabilitation protocols in zone II of the hand. Plastic and Reconstructive Surgery, 127 (4): 1583-1592, 2011. 31- Masoud M., Wani A.H. and Darzi M.A.: Topical heparin versus conventional treatment in acute burns: A comparative study. Indian Journal of Burns, 22 (1): 43, 2014