Evaluation of the Use of Skin Homograft for Management of Major Burn Patients

Document Type : Original Article

Authors

1 Faculty of Medicine, Menoufia University, Egypt

2 Faculty of Medicine, Menoufia University**, Egypt

3 The Department of Plastic and Reconstructive Surgery, Damietta Specialized Hospital, Damietta

Abstract

Objective: To evaluate the use of skin homograft in major
burn patients as regard indications, percentage of taking,
cosmetic outcome, cost, and complications. In addition to
comparing various laboratory data and notice the incidence
of systemic inflammatory response syndrome (SIRS) occurrence
pre-and post-operatively. And detect the mortality rate
among the patients managed with homograft.
Background: Burn is a type of physical trauma to skin or
tissue. It can be produced by heat, chemical products, cold,
electricity, or radiation. Burn can lead to loss of skin, resulting
in deep, widespread skin wounds or even death. Therefore,
finding an appropriate skin substitute in such patients is one
of the main concerns of clinicians.
Method: This prospective comparative study was done at
the Department of Plastic and Reconstructive Surgery, Menoufia
University Hospitals, from December 2017 to July 2020.
It was conducted on 31 patients with major burns; to evaluate
the use of skin homograft in major burn patients regarding
indications, the percentage of taking, the survival time, and
the complications. Also, to detect the incidence of occurrence
of systemic inflammatory response syndrome (SIRS) and the
mortality rate among the patients managed with homograft.
All studied patients and donors were subjected to take a full
history, general and local examination, investigations as
complete blood counts (CBC), blood glucose level, kidney
and liver function tests, electrolytes, and coagulation profile.
Also, preoperative preparation, intraoperative and postoperative
care was done.
Results: The present study revealed that there was a highly
significant decrease in postoperative temperature, heart rate,
respiratory rate, systemic inflammatory response (SIRS) score,
total leucocytic count (TLC), and K measurements in homograft
patients (p < 0.05 respectively). Comparative study
between pre-and post-operative measurements revealed; a
highly significant increase in post-operative albumin and Na
measurements in homograft patients (p < 0.05 respectively).
Conclusion: The current work concluded that the use of
homograft in major burn patients improved their overall
condition by improving laboratory and respiratory data postoperatively.
Furthermore, it reduces the raw area, reduces
fluid and electrolyte loss, and aids rapid wound healing.
Furthermore, we discovered a significant reduction in the
SIRS score, which reduces sepsis and improves morbidity
and mortality.

Keywords

Main Subjects

References

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