Mahmoud, N. (2020). Effect of Foam and Liquid Bleomycin in the Management of Venous Malformations in Head and Neck Region. A Comparative Study. The Egyptian Journal of Plastic and Reconstructive Surgery, 43(3), 401-408. doi: 10.21608/ejprs.2020.68170
Nada A Mahmoud. "Effect of Foam and Liquid Bleomycin in the Management of Venous Malformations in Head and Neck Region. A Comparative Study". The Egyptian Journal of Plastic and Reconstructive Surgery, 43, 3, 2020, 401-408. doi: 10.21608/ejprs.2020.68170
Mahmoud, N. (2020). 'Effect of Foam and Liquid Bleomycin in the Management of Venous Malformations in Head and Neck Region. A Comparative Study', The Egyptian Journal of Plastic and Reconstructive Surgery, 43(3), pp. 401-408. doi: 10.21608/ejprs.2020.68170
Mahmoud, N. Effect of Foam and Liquid Bleomycin in the Management of Venous Malformations in Head and Neck Region. A Comparative Study. The Egyptian Journal of Plastic and Reconstructive Surgery, 2020; 43(3): 401-408. doi: 10.21608/ejprs.2020.68170
Effect of Foam and Liquid Bleomycin in the Management of Venous Malformations in Head and Neck Region. A Comparative Study
The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Many treatment options for Venous Malformations (VM) has been documented in the literature but injection sclerotherapy has been considered a current mainstay for their treatment. We conducted this study to determine efficacy and durability of different injectable forms of bleomycin sclerotherapy in the treatment of VMs in cervico-facial region. Patients and Methods: Thirty patients complaining of venous malformation in the head and neck region, diagnosed clinically and confirmed by magnetic resonance imaging, had been injected with bleomycin sclerosing material. They were divided into two equal groups according to the form of bleomycin injected; Group A: Foam form was injected and Group B: Liquid form was injected. Patient's data, anatomical sites, type and volume of the VM, number of injection sessions and the average dose of injected agents were documented and statistically compared between the 2 groups. Results: MRI imaging showed a decline of more than 90% from the initial size of lesions in 66.7% cases and considerable decline (60%-90%) in 33.3% of cases. In Group A the number of sessions were (1-4), while in Group B were (1-6). the amount of sclerosing material injected in Group A were (2-7.5mg), while in Group B were (3.5-13mg), which was statistically significant. The cumulative dose in the equal size lesions was lower in the foam form rather than the liquid one, and show statistically significant difference. Conclusion: Foam form has greater promise compared with liquid form in the treatment of VMs and would encourage us to continue use the bleomycin in its foam form in the future on a bigger number of patients with larger size lesion and different location without reaching to the toxic cumulative life time dose.