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The Egyptian Journal of Plastic and Reconstructive Surgery
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Volume Volume 49 (2025)
Issue Issue 3
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Younes, B., Mandour, E., Shoukr, T. (2025). Laser-Assisted Drug Delivery in Early Post-Burn Hypertrophic Scars: Review Article. The Egyptian Journal of Plastic and Reconstructive Surgery, 49(3), 241-248. doi: 10.21608/ejprs.2025.444136
Bassel Mohammed Younes; El Sayed Mandour; Tarek G Shoukr. "Laser-Assisted Drug Delivery in Early Post-Burn Hypertrophic Scars: Review Article". The Egyptian Journal of Plastic and Reconstructive Surgery, 49, 3, 2025, 241-248. doi: 10.21608/ejprs.2025.444136
Younes, B., Mandour, E., Shoukr, T. (2025). 'Laser-Assisted Drug Delivery in Early Post-Burn Hypertrophic Scars: Review Article', The Egyptian Journal of Plastic and Reconstructive Surgery, 49(3), pp. 241-248. doi: 10.21608/ejprs.2025.444136
Younes, B., Mandour, E., Shoukr, T. Laser-Assisted Drug Delivery in Early Post-Burn Hypertrophic Scars: Review Article. The Egyptian Journal of Plastic and Reconstructive Surgery, 2025; 49(3): 241-248. doi: 10.21608/ejprs.2025.444136

Laser-Assisted Drug Delivery in Early Post-Burn Hypertrophic Scars: Review Article

Article 10, Volume 49, Issue 3, July 2025, Page 241-248  XML PDF (432.95 K)
Document Type: Review Article
DOI: 10.21608/ejprs.2025.444136
View on SCiNiTO View on SCiNiTO
Authors
Bassel Mohammed Younes email orcid ; El Sayed Mandour; Tarek G Shoukr*
The Department of Plastic & Reconstructive Surgery, Faculty of Medicine, Tanta University
Abstract
Hypertrophic scars and keloids arise from an excessive
healing process and frequently cause considerable distress to
patients. Fractional ablative lasers generate tiny channels in
the skin and penetrate scar tissue, prompting a natural regeneration
reaction in the damaged areas.
Laser-assisted drug delivery (LADD) is a promising therapeutic
technique that involves the direct application of drugs
that alter scars within the scar tissue via small channels.
Burn injuries stem from numerous etiologies, with hot liquids,
solids, and flames being the most common culprits. These
injuries pose a significant source of morbidity and can impact
on a patient’s quality of life, psychosocial well-being, and
socioeconomic burden. While advances in burn management
have reduced mortality rates, they have also led to a growing
number of patients experiencing sequelae, notably hypertrophic
scars (HTSs).
An overly accelerated healing process might result in hypertrophic
scars and keloids, which can sometimes cause significant
patient issues. One cutting-edge technique for accurately
distributing medications under the skin is laser-assisted drug
delivery, or LADD. LADD has proven to be quite successful
in treating burn injuries and scarring. They enable a speedy
recovery, are minimally intrusive, and have a low risk of adverse
consequences. Consequently, they are incorporated into
certain therapy protocols with other conservative and surgical
methods, which can be quite effective but also have a greater
likelihood of complications.

Keywords
Laser-Assisted Drug Delivery; Post-Burn
Main Subjects
New technologies and products
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