Zaki, A., Kadry, H., ALMALAHEY, H., Abol Hassan, M., Samy, A., Mostafa, S. (2025). Evaluation of the Effect of Fat Grafting in the Correction of Secondary Cleft Lip Deformities. The Egyptian Journal of Plastic and Reconstructive Surgery, 49(2), 135-148. doi: 10.21608/ejprs.2025.425146
Amr A Zaki; Hamed M. Kadry; HAYTHAMA A ALMALAHEY; Mamadouh Abol Hassan; Ahmed Samy; Shaimaa Mostafa. "Evaluation of the Effect of Fat Grafting in the Correction of Secondary Cleft Lip Deformities". The Egyptian Journal of Plastic and Reconstructive Surgery, 49, 2, 2025, 135-148. doi: 10.21608/ejprs.2025.425146
Zaki, A., Kadry, H., ALMALAHEY, H., Abol Hassan, M., Samy, A., Mostafa, S. (2025). 'Evaluation of the Effect of Fat Grafting in the Correction of Secondary Cleft Lip Deformities', The Egyptian Journal of Plastic and Reconstructive Surgery, 49(2), pp. 135-148. doi: 10.21608/ejprs.2025.425146
Zaki, A., Kadry, H., ALMALAHEY, H., Abol Hassan, M., Samy, A., Mostafa, S. Evaluation of the Effect of Fat Grafting in the Correction of Secondary Cleft Lip Deformities. The Egyptian Journal of Plastic and Reconstructive Surgery, 2025; 49(2): 135-148. doi: 10.21608/ejprs.2025.425146
Evaluation of the Effect of Fat Grafting in the Correction of Secondary Cleft Lip Deformities
The Department of Plastic Surgery, Faculty of Medicine, Cairo University
Abstract
Background: The individual with a cleft lip will require several surgical procedures during the patient early life. It is critical to prioritize treatment of secondary abnormalities and therefore reduce the number of necessary interventions. Objective: Fat grafting represents a minimally invasive technique, and we aimed to evaluate the effect of fat grafting in correcting secondary deformities post cleft lip repair. Patients and Methods: This prospective clinical trial includes 30 patients with secondary deformities post cleft lip repair. This study was conducted at Kasr El-Ainy, Cairo University Hospitals, Plastic Surgery Department, between October 2019 and May 2021. All patients received a fat injection to the lip and were evaluated using pre and postoperative ultrasonography and photo graphometry (image J), the Vancouver scar scale, and the patient satisfaction questionnaire. Results: There were statistically significant differences in scar width in bilateral cases (right scar 4.1062 Vs 3.7923) (left scar 3.7985 Vs 3.5146) and lip thickness in both unilateral and bilateral cases using ultrasonography, and statistically significant differences in scar width, vermilion Hight, and nasolabial angle by photograph meter, and statistically significant difference in preoperative and postoperative Vancouver scar scale, with overall very good patient satisfaction. Conclusions: Fat injection should be considered a therapeutic option in managing secondary lip deformities, particularly the volume deficiency, mild to moderate vermilion notching, and wide depressed scars, as it is a simple procedure with minimal and almost no complications.
1- Dixon M.J., Marazita M.L., Beaty T.H. and Murray J.C.: Cleft lip and palate: Understanding genetic and environmental influences. Nature Reviews Genetics, 12: 3 (12): 167–178, 2011. 2- Sarrami S.M., Skochdopole A.J., Ferry A.M., et al.: Revisional Techniques for Secondary Cleft Lip Deformities. Seminars in Plastic Surgery, 35: 65–71, 2021. 3- Koonce S.L., Grant D.G., Cook J. and Stelnicki E.J.: Autologous fat grafting in the treatment o cleft lip volume asymmetry. Annals of Plastic Surgery, 80: https://doi. org/10.1097/SAP.0000000000001348, 2018. 4- Samuel Stall: “Secondary deformities of cleft lip nose and palate.” In in plastic surgery, by Stephen Mathes, 393. philadelphia: Saunders, 2006. 5- Jackson IT. and Fasching M.C.: Secondary deformities of cleft lip, nose, and cleft palate. InMcCarthy JG, ed. Plastic and Reconstructive Surgery. Philadelphia: WB Saunders, 1990. 6- Baptista C., Bertrand B., Philandrianos C., Degardin N. and Casanova D.: [Autologous fat grafting in children]. Ann. Chir. Plast. Esthet, 61 (05): 732–739, 2016. 7- Shih L., Abu-Ghname A., Davis M.J., Xue A.S., Dempsey R.F. and Buchanan E.P.: Applications of Fat Grafting in Pediatric Patients. In Seminars in Plastic Surgery, Vol. 34, No. 01, pp. 053-058, 2020. Thieme Medical Publishers.
8- Jones C.M. and Mackay D.R.: Autologous fat grafting in cleft lip and palate. Journal of Craniofacial Surgery, 30: 686–691, 2019. https://doi.org/10.1097/SCS.0000000000005205. 9- Jones C.M., Morrow B.T., Albright W.B., Long R.E., Samson T.D. and Mackay D.R.: Structural fat grafting to improve reconstructive outcomes in secondary cleft lip deformity. Cleft Palate Craniofac. J., 54 (01): 70–74, 2017. 10- Zheng D., Zhou J., Yu L., et al.: Autologous Fat Transplantation to Improve Lip Contour in Secondary Cleft Lip Deformity. J. Craniofac. Surg., 31: 343–346, 2020. 11- Baum S.H., Rieger G., Pförtner R. and Mohr C.: Correction of whistle deformity using autologous free fat grafting: first results of a pilot study and review of the literature. Oral and Maxillofacial Surgery, 21: 409–418, 2017. 12- Young V3. 8, Jones C.M., Morrow B.T., Albright W.B., et al.: Structural fat grafting to improve reconstructive outcomes in secondary cleft lip deformity. Cleft Palate-Craniofacial Journal, 54: 70–74, 2017. 13- Ghareeb F., Elsakka D.M., Alkhateep Y. and Zayed H.M.: Improving esthetic outcome of facial scars by fat grafting. Menoufia Medical Journal, 30: 412, 2017. 14- Farid A.Y., ELhabaa G.I., Abdelmofeed A.M., et al.: Fat Grafting Techniques and Outcome in Scar Face. Benha Journal of Applied Sciences, 5: 289–295, 2020. 15- Duskova M., Kristen M.: Augmentation by autologous adipose tissue in cleft lip and nose. Final esthetic touches in clefts: Part I. Journal of Craniofacial Surgery, 15: 478–481, 2004. 16- Bae Y.C., Park T.S., Kang G. bin, et al.: Usefulness of microfat grafting in patients with repaired cleft lip. Journal of Craniofacial Surgery, 27: 1722–1726, 2016. 17- Zellner E.G., Pfaff M.J. and Steinbacher D.M.: Fat grafting in primary cleft lip repair. Plast. Reconstr. Surg., 135: 1449–1453, 2015.
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