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The Egyptian Journal of Plastic and Reconstructive Surgery
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Volume Volume 49 (2025)
Volume Volume 48 (2024)
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Khater, A., Takushima, A. (2024). The Full Motor Neurons Graft As a Preliminary Study in Rats. The Egyptian Journal of Plastic and Reconstructive Surgery, 48(3), 217-222. doi: 10.21608/ejprs.2024.365338
Amr Khater; Akihiko Takushima. "The Full Motor Neurons Graft As a Preliminary Study in Rats". The Egyptian Journal of Plastic and Reconstructive Surgery, 48, 3, 2024, 217-222. doi: 10.21608/ejprs.2024.365338
Khater, A., Takushima, A. (2024). 'The Full Motor Neurons Graft As a Preliminary Study in Rats', The Egyptian Journal of Plastic and Reconstructive Surgery, 48(3), pp. 217-222. doi: 10.21608/ejprs.2024.365338
Khater, A., Takushima, A. The Full Motor Neurons Graft As a Preliminary Study in Rats. The Egyptian Journal of Plastic and Reconstructive Surgery, 2024; 48(3): 217-222. doi: 10.21608/ejprs.2024.365338

The Full Motor Neurons Graft As a Preliminary Study in Rats

Article 8, Volume 48, Issue 3, July 2024, Page 217-222  XML PDF (595.66 K)
Document Type: Research article
DOI: 10.21608/ejprs.2024.365338
View on SCiNiTO View on SCiNiTO
Authors
Amr Khater* 1; Akihiko Takushima email 2
1The Department of Plastic Surgery, Faculty of Medicine, Mansoura University, Egypt
2Kyorin University School of Medicine, Tokyo
Abstract
Background: Conventional nerve grafting was used for
treatment of nerve defects. However, the slow rate of nerve
regeneration, donor site limitations and morbidities were considered
the major disadvantages of this technique.
Objective: In this article, a novel motor neuron nerve allografts
were used to accelerate nerve regeneration and were
compared to nerve allograft in a rat model.
Methods: We harvested full motor neuron grafts and conventional
nerve grafts and used them to reconstruct a ten mm
defect in the motor nerve to the Extensor Digitorum communis
(EDC).
Results: Histological examination confirmed intact connections
between the motor neurons and its axons. The mean
of the amplitudes of evoked potentials of neuron graft group < br />and conventional graft group were 12.2±3.6 milliampere and
8.0±6.0 milliampere. However, muscle force, muscle weight
and histological examination showed insignificant differences
between the two groups.
Conclusion: Full neuron transfer is a new type of nerve
grafts in the rat model. As a preliminary report, we investigated
the viability of the transferred nerve cells and if they worked as
a booster for augmentation of the signals. Electrophysiological
examinations showed favorable results and histological studies
showed the survival of the motor neurons outside the central
nervous system.
Keywords
Neuron graft; Nerve graft – Wallerian degeneration – Nerve regeneration
Main Subjects
Microsurgery
Supplementary Files
download Sur.7 (1).pdf
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