Mabrouk, A., Fahmy, H., Mabrouk, A., Hammad, M., Badawy, M. (2024). Use of Lyophilized Growth Factors Foam in Chronic Ulcers. The Egyptian Journal of Plastic and Reconstructive Surgery, 48(3), 211-216. doi: 10.21608/ejprs.2024.365335
Adel Mabrouk; Hossam M Fahmy; Amr Mabrouk; Mai Raafat Hammad; Mohamed Samir Badawy. "Use of Lyophilized Growth Factors Foam in Chronic Ulcers". The Egyptian Journal of Plastic and Reconstructive Surgery, 48, 3, 2024, 211-216. doi: 10.21608/ejprs.2024.365335
Mabrouk, A., Fahmy, H., Mabrouk, A., Hammad, M., Badawy, M. (2024). 'Use of Lyophilized Growth Factors Foam in Chronic Ulcers', The Egyptian Journal of Plastic and Reconstructive Surgery, 48(3), pp. 211-216. doi: 10.21608/ejprs.2024.365335
Mabrouk, A., Fahmy, H., Mabrouk, A., Hammad, M., Badawy, M. Use of Lyophilized Growth Factors Foam in Chronic Ulcers. The Egyptian Journal of Plastic and Reconstructive Surgery, 2024; 48(3): 211-216. doi: 10.21608/ejprs.2024.365335
Use of Lyophilized Growth Factors Foam in Chronic Ulcers
1The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Ain Shams University
2The Department of Laboratory & Transfusion Medicine, Faculty of Medicine, Ain Shams University
3The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Ain Shams University
4The Department of Plastic, Burn, and Maxillofacial Surgery, Faculty of Medicine, Ain Shams University
Abstract
Background: Treatment of chronic ulcers involves addressing the underlying cause and interventions to improve the process of healing such as autologous platelet-rich plasma. Platelet-rich plasma has been extensively studied for its potential in promoting healing of chronic ulcers as it contains a high concentration of growth factors such as platelet derived growth factor, epithelial growth factor and fibroblast growth factor. Advanced growth factor delivery systems have been developed to prolong the bio-activity of growth factors. LGF have been developed by a patented method to overcome the discrepancies of conventional platelet rich plasma. Objective: In this study, we present LGFoam as a topical agent containing Lyophilized growth factors, for use in chronic lower limb ulcers for the purpose of improving healing. Methodology: Comparison of ulcer size between LGFoam topically applied to non-healing lower limb ulcers of various etiologies, as opposed to conventional dressing with a 30-day follow-up period. Conclusion: Several advanced growth factors delivery systems have been developed for topical use. However, conflicting evidence exists for their efficacy, warranting further research. In our study, there was a statistically significant decrease in ulcer size for the LGFoam group, encouraging future studies into its use in promoting wound healing in general, especially chronic non-healing ulcers as a problematic entity.
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