Abdelhalim, M., Gadallah, A., Ghanem, M., Mohamed, S., Fekry, M. (2024). The Role of Serum Procalcitonin as a Diagnostic and Prognostic Biomarker for Sepsis in Major Burn Patients: A Prospective Study. The Egyptian Journal of Plastic and Reconstructive Surgery, 48(2), 91-97. doi: 10.21608/ejprs.2024.352130
Mohamed M. Abdelhalim; Ahmed Gadallah; Mohamed Abdelmohsen Ghanem; Salah N. Mohamed; Mohamed Fathy Fekry. "The Role of Serum Procalcitonin as a Diagnostic and Prognostic Biomarker for Sepsis in Major Burn Patients: A Prospective Study". The Egyptian Journal of Plastic and Reconstructive Surgery, 48, 2, 2024, 91-97. doi: 10.21608/ejprs.2024.352130
Abdelhalim, M., Gadallah, A., Ghanem, M., Mohamed, S., Fekry, M. (2024). 'The Role of Serum Procalcitonin as a Diagnostic and Prognostic Biomarker for Sepsis in Major Burn Patients: A Prospective Study', The Egyptian Journal of Plastic and Reconstructive Surgery, 48(2), pp. 91-97. doi: 10.21608/ejprs.2024.352130
Abdelhalim, M., Gadallah, A., Ghanem, M., Mohamed, S., Fekry, M. The Role of Serum Procalcitonin as a Diagnostic and Prognostic Biomarker for Sepsis in Major Burn Patients: A Prospective Study. The Egyptian Journal of Plastic and Reconstructive Surgery, 2024; 48(2): 91-97. doi: 10.21608/ejprs.2024.352130
The Role of Serum Procalcitonin as a Diagnostic and Prognostic Biomarker for Sepsis in Major Burn Patients: A Prospective Study
The Department of Plastic, Burn and Maxillofacial Surgery, Faculty of Medicine, Ain Shams University
Abstract
Background: Sepsis in burns worsens the patient’s prognosis and increases the risk of organ failure and death. Multiple organ dysfunction syndrome (MODS), which is a direct response to sepsis is the main reason for death in burn patients. Identifying early sepsis is especially important, given that every 6h delay in the diagnosis of sepsis reduces survival by 10%. Complexity in diagnosing sepsis in the burn is due to the systemic response to the burn itself clinically simulating sepsis. Objective: The aim of this study is: To investigate the diagnostic validity of PCT in burn sepsis as an early diagnostic tool and to identify its prognostic value in major burn patients with sepsis. Patients and Methods: The study was a prospective study that was conducted in a six months period carried out in the Burn Intensive Care Unit (ICU) of Ain Shams University Hospitals on 30 patients that were admitted from October 2021 to March 2022 with major burn (more than 20% of TBSA) were included, the Local Ethics Committee approved the study, and informed consent was obtained from all participants or their guardians. Results: It had been revealed that the first 3 samples that were drowned on admission and after 24 hours and then on day 3 of admission have no significant increase in PCT levels in relation to sepsis. However, the following 2 samples which had been withdrawn on day 5 show a significant increase in PCT levels, and these on day 7 are highly significant with a median (IQR) range of 9ng/dl and median (IQR) range of 13.2ng/dl respectively. Moreover, it had been noted that the PCT level on admission was significant for the prognosis of death with a median (IQR) range of 1.65ng/dl while in survivor patients the median was 0.45ng/dl. Conclusion: Our study demonstrated that PCT level in major burn patients is a promising diagnostic biomarker in detecting sepsis that could facilitate ideal management and initiate proper antimicrobial therapy and good prognostic value as an early predictor of mortality.
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