El Nagar, A., Khalil, A., El Hawary, A., Sheba Eldin, S., Bahaa, A. (2018). Comparative Study between Negative Pressure Wound Therapy and Platelet Rich Plasma in Neovascularization of Chronic Wound Healing. The Egyptian Journal of Plastic and Reconstructive Surgery, 42(1), 35-43. doi: 10.21608/ejprs.2018.214975
Ahmed G. El Nagar; Ahmed A. M. Khalil; Amira K. El Hawary; Sami Sheba Eldin; Ahmed M. Bahaa. "Comparative Study between Negative Pressure Wound Therapy and Platelet Rich Plasma in Neovascularization of Chronic Wound Healing". The Egyptian Journal of Plastic and Reconstructive Surgery, 42, 1, 2018, 35-43. doi: 10.21608/ejprs.2018.214975
El Nagar, A., Khalil, A., El Hawary, A., Sheba Eldin, S., Bahaa, A. (2018). 'Comparative Study between Negative Pressure Wound Therapy and Platelet Rich Plasma in Neovascularization of Chronic Wound Healing', The Egyptian Journal of Plastic and Reconstructive Surgery, 42(1), pp. 35-43. doi: 10.21608/ejprs.2018.214975
El Nagar, A., Khalil, A., El Hawary, A., Sheba Eldin, S., Bahaa, A. Comparative Study between Negative Pressure Wound Therapy and Platelet Rich Plasma in Neovascularization of Chronic Wound Healing. The Egyptian Journal of Plastic and Reconstructive Surgery, 2018; 42(1): 35-43. doi: 10.21608/ejprs.2018.214975
Comparative Study between Negative Pressure Wound Therapy and Platelet Rich Plasma in Neovascularization of Chronic Wound Healing
1The Department of Plastic Surgery, Ahmed Maher Teaching Hospital, Cairo ; Egypt
2The Departments of Plastic Surgery, Faculty of Medicine, Mansoura University
3The Departments of Pathology Faculty of Medicine, Mansoura University
4The Departments of Plastic Surgery** , Faculty of Medicine, Mansoura University
Abstract
Background: Chronic wound healing is a significant health problem. Increased angiogenesis and blood flow had been shown to facilitate the healing of chronic wounds. Negative pressure wound therapy and platelet rich plasma may be used for treatment of various chronic wounds, especially when standard conventional therapy is not good enough or for preparation for definitive closure. Objectives: To compare the efficacy of negative pressure wound therapy and platelet rich plasma in neovascularization of chronic wound healing. Patient and Method: Twenty patients with chronic wound were divided into two groups. Wound tissue biopsies were collected from the centeraland peripheral of the wound before starting our procedure and after one, two and three weeks in both groups. Evaluation of the wound clinically and Immunohistochemically for vascular endothelial growth factor (VEGF) and CD31 (cluster of differentiation) were done. Results: PRP and NPWT were effective in neovasculization and stimulation of healing process. The expression of VEGF in PRP patients after the third week was mild 10%, moderate 20%, strong 70% and was mild 10%, moderate 20%, strong 70% in peripheral and central tissue biopsy respectively. While in NPWT patient was mild 20%, moderate 30%, strong 50% in both peripheral and central tissue biopsy. The average of blood vessels formation in CD-31 was 9.95±3.64 after 3 week in peripheral tissue biopsy and was 8.58±3.51 in central tissue biopsy in PRP patients. While in NPWT patients was 8.35±3.25 in peripheraltissue biopsy and was 8.38±3.12 in central tissue biopsy. Conclusion: PRP and NPWT are effective in treatment chronic wounds. PRP is more simple, less costly, shorter time for the method, less painful, no hospital stay and less transmission of infections.
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