Senada, M., Adel Rahman, S., Saleh, M., Alhamoudy, N., Hammam, G. (2021). The Effect of Platelet-Rich Fibrin on Donor Site of Split Thickness Skin Graft in Burned Patients. The Egyptian Journal of Plastic and Reconstructive Surgery, 45(4), 313-318. doi: 10.21608/ejprs.2021.201654
Mina R.S. Senada; Sameh Adel Rahman; Mohamed A. A. Saleh; Niveen F Alhamoudy; Ghada G. Hammam. "The Effect of Platelet-Rich Fibrin on Donor Site of Split Thickness Skin Graft in Burned Patients". The Egyptian Journal of Plastic and Reconstructive Surgery, 45, 4, 2021, 313-318. doi: 10.21608/ejprs.2021.201654
Senada, M., Adel Rahman, S., Saleh, M., Alhamoudy, N., Hammam, G. (2021). 'The Effect of Platelet-Rich Fibrin on Donor Site of Split Thickness Skin Graft in Burned Patients', The Egyptian Journal of Plastic and Reconstructive Surgery, 45(4), pp. 313-318. doi: 10.21608/ejprs.2021.201654
Senada, M., Adel Rahman, S., Saleh, M., Alhamoudy, N., Hammam, G. The Effect of Platelet-Rich Fibrin on Donor Site of Split Thickness Skin Graft in Burned Patients. The Egyptian Journal of Plastic and Reconstructive Surgery, 2021; 45(4): 313-318. doi: 10.21608/ejprs.2021.201654
The Effect of Platelet-Rich Fibrin on Donor Site of Split Thickness Skin Graft in Burned Patients
1The Department of Plastic, Burn & Maxillofacial Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2The Department of Histology & Cell Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Patients with massive burn areas have now a greater chance of survival thanks to improved modalities of new treatments. In some patients it is necessary to harvest multiple skin grafts from the same donor site which is restricted by the quality of the skin and the time required to recover; this procedure can take a long time and may increase the danger of bacterial contamination resulting in increased morbidity and mortality in these individuals. Platelet-rich fibrin is one of the newest autologous growth factors utilized for wound management. PRF application can significantly improve the wounds' condition by supplying growth factors to the wound environment, which aid in the epithelialization process's acceleration, resulting in cost-effective wound management. This will allow multiple harvesting from the same donor site, reducing costs, hospitalization time, scars, and co-morbidities. Aim of the Work: To assess the role of PRF in accelerating wound healing in the donor site following skin grafting in burn patients. Patients and Methods: This prospective, controlled, clinical trial study was done from April 2020 to April 2021 included 20 patients at the burn unit of El Demerdash Hospital, Ain Shams University. Results: The current study showed that healing days in donor sites injected with PRF were lower than those of controlled areas with statistical significance and mean epidermal thickness was lower in the control area compared to PRF injected areas with statistical significance. Conclusion: PRF can significantly decrease the time of donor wound healing compared to that of conventional treatment.
Reksodiputro M.H., Harba'i H.M., Koento T. and Harahap A.R.: Platelet-rich fibrin enhances wound epithelialization in the skin graft donor site. Journal of Physics: Conference Series, 1073: 032046, 2018. 2- Danielsen P., Jørgensen B., Karlsmark T., Jorgensen L.N. and Ågren M.S.J.P.: Surgery R. Effect of topical autologous platelet-rich fibrin versus no intervention on epithelialization of donor sites and meshed split-thickness skin autografts: A randomized clinical trial, 122 (5): 1431-40, 2008. 3- Hotwani K. and Sharma K.: Platelet-rich fibrin-a novel acumen into regenerative endodontic therapy. Restorative Dentistry & Endodontics, 39 (1): 1-6, 2014. 4- Somani A. and Rai R.: Comparison of the efficacy of autologous platelet-rich fibrin versus saline dressing in chronic venous leg ulcers: A randomized controlled trial. Journal of Cutaneous and Aesthetic Surgery, 10 (1): 8, 2017. 5- Sclafani A.P.: Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery. Archives of Facial Plastic Surgery, 13 (4): 247, 2011. 6- Singh A., Kohli M. and Gupta N.: Platelet-rich fibrin: A novel approach for osseous regeneration. Journal of Maxillofacial and Oral Surgery, 11 (4): 430-4, 2012. 7- Miron R.J., Fujioka-Kobayashi M., Hernandez M., Kandalam U., Zhang Y., Ghanaati S., et al.: Injectable plateletrich fibrin (i-PRF): Opportunities in regenerative dentistry? Clinical Oral Investigations, 21 (8): 2619-27, 2017. 8- Suvarna S. and Layton C.: Bancroft's theory and practice of histological techniques, 7th ed. Churchill Livingstone Elsevier. Oxford, 2013. 9- Vaheb M., Karrabi M., Khajeh M., Asadi A., Shahrestanaki E. and Sahebkar M.J. Tijolew: Evaluation of the effect of platelet-rich fibrin on wound healing at split-thickness skin graft donor sites: A randomized, placebo-controlled, triple-blind study, 20 (1): 29-36, 2021. 10- Kakudo N., Kushida S., Minakata T., Suzuki K. and Kusumoto K.J. Mmm: Platelet-rich plasma promotes epithelialization and angiogenesis in a split-thickness skin graft donor site, 44 (4): 233-6, 2011. 11- Fang Z., Yang X., Wu G., Liu M., Han J., Tao K., et al.: The use of autologous platelet-rich plasma gel increases wound healing and reduces scar development in splitthickness skin graft donor sites. Journal of plastic surgery and hand surgery, 53 (6): 356-60, 2019. 12- Ferreira L.M., Blanes L., Gragnani A., Veiga D.F., Veiga F.P., Nery G.B., et al.: Hemicellulose dressing versus rayon dressing in the re-epithelialization of split-thickness skin graft donor sites: A multicenter study, 18 (3): 88-94, 2009. 13- Kaiser D., Hafner J., Mayer D., French L.E. and Läuchli S.J. Ais: Care W. Alginate dressing and polyurethane film versus paraffin gauze in the treatment of split-thickness skin graft donor sites: A randomized controlled pilot study, 26 (2): 67-73, 2013. 14- Dohan Ehrenfest D.M., de Peppo G.M., Doglioli P. and Sammartino G.J.G.F.: Slow-release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies, 27 (1): 63-9, 2009. 15- Dohan Ehrenfest D.M.J.O.S.: Oral medicine, oral pathology, oral radiology, endodontics. How to optimize the preparation of leukocyte-and platelet-rich fibrin (L-PRF, Choukroun's technique) clots and membranes: Introducing the PRF Box., 110 (3): 275-8, 2010. 16- Dohan D.M., Choukroun J., Diss A., Dohan S.L., Dohan A.J., Mouhyi J., et al.: Platelet-rich fibrin (PRF): A secondgeneration platelet concentrate. Part I: Technological concepts and evolution. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 101 (3): e37- 44, 2006. 17- Khanzadeh Alishahi M., Kazemi D., Mohajeri D., Mofidpoor H., Afkhami Goli A., Khanzadeh Alishahi MAJIJoVS, et al.: Histopathological evaluation of the effect of plateletrich fibrin on canine cutaneous incisional wound healing, 5 (2): 19-32, 2013. 18- Majeed A.A. and Abood DAJVW.: Histological assessment of the efficiency of rabbit serum in healing skin wounds, 12 (10): 1650, 2019. 19- Del Amo C., Perez-Valle A., Perez-Zabala E., Perez-del- Pecho K., Larrazabal A., Basterretxea A., et al.: Wound Dressing Selection Is Critical to Enhance Platelet-Rich Fibrin Activities in Wound Care, 21 (2): 624, 2020. 20- Tsai H-C., Chang GR-L., Fan H-C., Ou-Yang H., Huang L-C., Wu S-C., et al.: A mini-pig model for evaluating the efficacy of autologous platelet patches on induced acute full-thickness wound healing, 15 (1): 1-13, 2019. 21- Xu F., Zou D., Dai T., Xu H., An R., Liu Y., et al.: Effects of incorporation of granule-lyophilized platelet-rich fibrin into polyvinyl alcohol hydrogel on wound healing, 8 (1): 1-10, 2018. 22- Khalafı F.H. and SALIH SIJAJPCR: Clinical and histopathological evaluation of using platelet-rich plasma and platelet-rich fibrin matrix in the treatment of induced chronic open wounds in bucks, 11 (5): 337-41, 2018
View on SCiNiTO
Top